De novo pyrimidine and purine synthesis: Drugs

Leflunomide is an oral drug that is rapidly absorbed from the gastrointestinal tract. Once absorbed, LEF is converted to its active form, a malononitrilamide known as teriflunomide, doses given for rheumatoid arthritis is inhibition of the synthesis of a pyrimidine known as ribonucleotide uridine monophosphate pyrimidine (rUMP). Teriflunomide, the active metabolite of Leflunomide, was found effective in patients with multiple sclerosis and is available for use in that condition

Hydroxyurea is in a class of medications called antimetabolites. Hydroxyurea treats cancer by slowing or stopping the growth of cancer cells in your body through the pyrimidine pathway. Hydroxyurea treats sickle cell anemia by helping to prevent formation of sickle-shaped red blood cells. The most i could get out of this drug is that it really kills the body to stop something else from killing the body.

6-Mercatopurine is whose trade name is purinethol is an anti cancer (antineoplastic or cytoxic) chemotherapy drug. the medication is described as antimetabolite. Specifically used for Acute lumphoblastic leukemia (ALL).Has some side effects like infertility, diarrhea, mouth sores (higher dosage).Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division. If the cells are unable to divide, they die. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide (self-death or apoptosis).