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Post by Admin on Jan 24, 2016 22:57:35 GMT
A 55-year-old comedian from Arizona comes to the physician with an x-ray film of her chest taken during a routine health insurance examination. The x-ray film shows bilateral hilar adenopathy. The patient is completely asymptomatic. Sarcoidosis is suspected. He was told that his serum levels of angiotensin-converting enzyme (ACE) were elevated. The sensitivity and specificity of using ACE levels to test for the disease in question are 80% and 50%, respectively. Assuming that sarcoidosis is highly prevalent in this patient's community, how would the patient's place of residence affect the positive predictive value (PPV) and negative predictive value (NPV) of the test?
A. In areas of higher prevalence, both the PPV and the NPV are higher B. In areas of higher prevalence, both the PPV and the NPV are lower C. In areas of higher prevalence, the PPV is higher and the NPV is lower D. In areas of higher prevalence, the PPV is lower and the NPV remains the same E. Regardless of the prevalence, both the PPV and the NPV are unchanged
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Post by Admin on Jan 24, 2016 23:02:12 GMT
What is Sarcoidosis?
- Sarcoidosis is a systemic granulomatous disease of unknown origin that particularly involves the lungs. - The pathologic hallmark is the presence of noncaseating granulomas. - Bilateral hilar adenopathy can be the presenting sign in asymptomatic patients with sarcoidosis. - Sarcoidosis is associated with increased levels of angiotensin-converting enzyme (ACE), but testing serum ACE levels does not provide a definitive diagnosis of sarcoidosis because of the relatively low specificity and sensitivity of the test. - Nevertheless, for any given test, the probability that a positive test result is truly positive for the disease one is looking for increases as the prevalence of the disease increases. - The probability that a negative test result is a truly negative for the disease one is looking for decreases as the prevalence of the disease increases. - There is significant regional variation in the incidence of sarcoidosis, but the reasons for this variation are not well understood.
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