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Post by Admin on Feb 15, 2016 1:31:27 GMT
1. If you were to search Medline for original research on one of these questions, describe what your search strategy would be. Be as specific as you can about which topics and search categories (fields) you would search. Explain your rationale for taking this approach. Describe how you might limit your search if necessary and explain your reasoning 2. Choose to focus on one of the clinical scenarios (breastfeeding and oral contraceptives, or bedwetting alarm). What type of stu dy (study design) would best be able to address this question? Why? Use the link below to read and select which one is best for your topic. himmelfarb.gwu.edu/tutorials/studydesign101/ |
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febi
New Member
Posts: 4 
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Post by febi on Feb 18, 2016 18:41:14 GMT
1). Search topics would include:
- Safe therapeutic options for asthma
- Drug-interactions with asthma medications
- Therapy for asthma and T.B infections
Categories to be searched include: age group (because asthma is more common in children), publication date (because I want up-to-date information).
2). Appropriate study design:
Randomized Controlled Trial: This design is good to examine the difference between two or more therapeutic options for the same disease. The population for my case will be clearly defined as people with asthma and T.B infection concurrently. It will be easy to see the effects of the different kinds of medications and combinations on the population.
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Post by goodness on Feb 19, 2016 7:04:12 GMT
1. Specifically searching out the research Topics:
A) Complications of smoking
B) Causes of lung cancer
C) Relationship between smoking and lung cancer
Categories:
A) Age group
B) Education
C) Validity
D) Publication date
Selecting age group because of different prevalence of smoking in different age group and in relation to education, it is proven that uneducated individuals are more likely to be smokers compared to educated individuals. I am also going with validity because most researches are not all round valid due to research limitations. And in the case of publication date, the more recent the publication is the more likely of it to be valid.
2. Best study design
Cohort Study
Because it produces Clarity of Temporal Sequence (Did the exposure precede the outcome?): Cohort studies more clearly indicate the temporal sequence between exposure and outcome, because in a cohort study, subjects are known to be disease-free at the beginning of the observation period when their exposure status is established. It also allow calculation of incidence which will be good in this case, etc.
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Post by hyasin on Feb 20, 2016 0:22:33 GMT
Bedwetting Alarm
1. Search Topics:
A) age range
B) effectiveness
C) design features
D) causes of bedwetting
E) correlation with sex
F) publication date
Publication date is important in order to pick relevant up-to-date data to include. Design features could make the alarm more effective. Some features may make it more effective for children, while others would make it more effective for the elderly.
2. Study Design:
Meta-Analysis
Chose this because it will systematically combine pertinent qualitative and quantitative study data from several selected studies to develop a single conclusion that has greater statistical power.
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Post by Kaweng on Feb 21, 2016 13:31:04 GMT
1.Regarding the Topic Lassa fever
a. Topics to be search on Medline would include
- Countries most prevalent to Lassa fever
- Main predispose cause
- Complications of viral hemorrhagic fever.
- Current treatment
- Post treatment care
b. Categories
- regions, social class, population with bush meat included in their diet.
The topics to be search are chosen because the disease itself have a self prevalence to some certain regions. The disease can reach a complicated stage when left untreated, at this stage treatment is limited and also post care of cured patients is relevant because it sheds light on how future patients can be manage. The categories to be searched for does not include age range as the disease affects all ages, however social class and population who consume bush meat as staple is of utmost importance as the disease spreads through these categories.
2. Breast feeding and Oral contraceptives
Study Design - Meta-Analysis
This study design is best for evaluating breastfeeding and oral contraceptives because breastfeeding and oral contraceptives are two quality and quantitative datas that are compared with enough evidence hence a greater statistical power. There is a greater chance of having an increase number of subjects, greater diversity with prospective accumulative results among subjects. As not all breastfeeding mothers use oral contraceptives and not all oral contraceptive users are breastfeeding, Meta-Analysis will establish a statistical significance between the two conflicting datas, it will also provide a better understanding of the safety and benefits of using oral contraceptives whilst breastfeeding and when not breastfeeding and also the harm in each case. As the study group is diverse, using randomized controlled trials will propel enough evidence with reviews. The pros of using meta-analysis for this study design boils down to the fact that there is a greater statistical power with a stern confirmatory data analysis and also it is an evidence based resource that can be propel to the population affected. However as all study designs, Meta-analysis has a few cons of its own; these includes the time required and the subjects loyalty to taking the contraceptives
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Post by roxanne on Feb 21, 2016 15:35:56 GMT
Search topics
1. Metabolic syndrome associated with lipoprotein metabolism
2. Therapeutic options for metabolic syndrome
• Statins: potent pharmacolgical agent for lowering LDL but has small efect on increasing HDL
3. Test to monitor under prescribed drugs to check toxicity
4. Drug interactions
• bile-sequestering resins with other drugs
• Statins and fibrates
5. Protocol in diagnosing metabolic syndrome
6. Management of metabolic syndrome to control factors such as:
• Weight control
• Improve lipid profile
• Increase insulin sensitivity
• Decrease blood pressure
Search categories
1. Age group: post-menopausal women
• Metabolic syndrome is common in this age group
2. Publication date
3. Subject terms
4. Scholarly publications
Clinical scenario to focus on would be therapeutic options (drug-drug interactions)
Analytic observational study would be the best study design that would address this question. Moreover, meta analysis would be best because of the great diversity of the case, different effects and results, and it provides a more complex analysis of harms, safety data and benefits of the current pharmacological interventions of metabolic syndrome and lipoprotein metabolism.
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Post by bukunmi on Feb 21, 2016 18:47:37 GMT
A 42 years old man called into the emergency room due to severe weakness in the legs. During history taking and examination I discovered that he drinks alot,has Myesthenia Gravis and have had recent infection of pneumonia. Further studies showed that he has been taking an aminoglycoside for the infection.
I instructed the stoppage of the medication and recommended the use of Cifotaxime instead because aminoglycosides exacerbates weakness in Myesthenia gravis.
1) Medline search topics:
- Myasthenia Gravis in alcoholics
- Effect of bacteria infection in myasthenia gravis
- Best treatment for myasthenia gravis
- Other drugs that exacerbates weakness in myasthenia gravis
Categories to be considered include: Alcoholics, gender differences, age of onset.
2) Study design: Systematic review
This design was chosen because it will provide a comprehensive review of all relevant studies on myasthenia gravis and the related medication approach, including superimposed bacterial infections. The systematic review is created after reviewing and combining all the information from both published and unpublished studies (focusing on clinical trials of similar treatments of (recurrent) infections in mysthenia gravis patients i.e Cifotaxime vs. aminoglycosides) and then summarizing the findings.
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Post by rehman on Feb 21, 2016 22:19:01 GMT
Medline Search Topics
-Penicillin substitutes for strep infections
-Non toxic medications
-Aspirin substitutes
-What effects would slow treating strep cause
Study Design
- Meta-Analysis
The reason this design would work good for this study is because it will take the evidence from other studies and provide the benefits that the found in their research as well as the risks and any harmful side effects. This design gives results on a statistical basis which will short the percentage frequency of each topics in a comparable form. This will allow someone to see in what instance others had success in their scenario and can decide the appropriate action to take from there.
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Post by azaidi9213 on Feb 22, 2016 2:17:57 GMT
1) Search Topics - pulmonary embolism
- heparin
- thrombolytic therapy
- thrombolytic therapy with pulmonary embolism patients
2) Study design: Randomized control trial because the control can be the usual treatments given to a patient with pulmonary embolism, for instance heparin and then the controversial thrombolytic therapy for the other group of patients that have had a pulmonary embolism. Since it will be random it will give a clear picture statistically how a patient that has had a pulmonary embolism will react when given to throbolytic therapy, and what the effects as a result of the treatment.
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Post by avazifdar on Feb 22, 2016 2:38:31 GMT
1) Search topics
a. New onset diabetes
b. Alcohol interaction with metformin
c. Therapy for diabetic control
The topics were chosen because they are broad enough where information can be found, but are specific enough to gain new knowledge. Search limitations may include the validity of the article or information. Some information may be outdated.
2) Oral contraceptives-A randomized control trial can randomly assign participants into an experimental group or a control group. As the study is conducted, the only expected difference between the control and experimental groups is randomized controlled trial (RCT) is the the outcome variable being studied.
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Post by waliul on Feb 22, 2016 4:56:52 GMT
1) Search Topics:
-Theophylline and macrolides drug interaction
-Complications of Asthma with pulmonary infections
-Safest treatment for asthma with pulmonary infection
-Pulmonary infection treatment with less side effects
My strategy is to limit my search to the treatment involving Asthma with pulmonary infection. I am looking for results to show interactions between drugs for asthma and pulmonary infection. I am also looking for alternative treatments that will give less side effects.By putting in words like macrolides or pulmonary infection treatment, I'm trying to get results related to Erythromycin and Azithromycin drug treatment.
2)Study Design:
Randomized Clinical Trial:
This will help with answering if Azithromycin with Theophylline is a safer dual drug treatment that Erythromycin and Theophylline. By comparing these 2 groups in separate trials, the results can be observed by looking for side effects in each group; one group taking theophylline with erythromycin and the other group taking theophylline with Azithromycin. These participants should be patients with both a history of asthma and having a pulmonary infection. The advantage is that the 2 groups can be analyzed and compared; which can help answer the question between the drug interactions. Also, since it is a randomized study, the risk of population bias becomes less. Also the participants that are involved in the study are clearly identified.
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Post by sarasareen on Feb 22, 2016 9:51:00 GMT
1) Search Topics
• Bipolar Disorder
• Mood Stabilizers
• Depakote
• Lamictal
• Lithium
2) Study Design:
I chose randomized controlled trial for my study design because it will allow me to examine the difference between the two therapeutic options Lamictal and Depakote for the treatment of Bipolar disorder. Good randomization will remove any population biases I may face and populations of participating individuals will be identified. One disadvantage that I would face is that this study design is costly, and I would also need to watch out for volunteer bias.
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Post by sauitee on Feb 22, 2016 11:59:37 GMT
1.searching out the research Topics:
Tuberculosis
Causes of tuberculosis.
2.Study design
age group
control
year it has been published
place /country
Selecting age group to see which age is more likely to get this disease. The control would allow me to differentiate between the normal and the diseased. Year of publication would tell me which year was had the most cases of TB and place or country would be important to explain which country and the most cases of TB and why.
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